How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …

Impact of early antiretroviral therapy, early life immunity... : Current Opinion in HIV and AIDS
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV …

Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …

An effective strategy to cure HIV will likely require a potent and sustained antiviral T cell
response. Here we explored the utility of chimeric antigen receptor (CAR) T cells, expressing …

Introduction Immunological damage in acute HIV infection (AHI) may predispose to
detrimental clinical sequela. However, studies on the earliest HIV-induced immunological …

An effective human immunodeficiency virus type 1 (HIV-1) vaccine is the best solution for
halting the acquired immune deficiency syndrome epidemic. Here, we describe the design …

Heterosexual transmission of HIV-1 is characterized by a genetic bottleneck that selects a
single viral variant, the transmitted/founder (TF), during most transmission events. To assess …

Immune activation during acute HIV infection and the impact... : Current Opinion in HIV and
AIDS Immune activation during acute HIV infection and the impact of early antiretroviral therapy …

The knowledge of untreated and treated AHI informs the development of vaccines, in that
preventive vaccines will require broad coverage for multiple clades and antigenic variants …

Highlights•HIV-1 within-host evolution is short-sighted and favours more virulent
viruses.•Systemic HIV-1 infection is mainly established by a single variant …