Itch: from mechanism to (novel) therapeutic approaches

G Yosipovitch, JD Rosen, T Hashimoto - Journal of allergy and clinical …, 2018 - Elsevier
Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …

Mediators of chronic pruritus in atopic dermatitis: getting the itch out?

NK Mollanazar, PK Smith, G Yosipovitch - Clinical reviews in allergy & …, 2016 - Springer
For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis

HC Rayner, M Larkina, M Wang… - Clinical journal of the …, 2017 - journals.lww.com
Results Patients very much or extremely bothered by itching declined from 28% in 1996 to
18% in 2015. In 2012–2015, among patients nearly always or always bothered by itching …

[HTML][HTML] Self-reported pruritus and clinical, dialysis-related, and patient-reported outcomes in hemodialysis patients

N Sukul, A Karaboyas, PA Csomor, T Schaufler, W Wen… - Kidney medicine, 2021 - Elsevier
Rationale & Objective Chronic kidney disease (CKD)-associated pruritus, generalized
itching related to CKD, affects many aspects of hemodialysis patients' lives. However …

The vicious cycle of itch and anxiety

KM Sanders, T Akiyama - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn,
stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior …

Sleep disorders, restless legs syndrome, and uremic pruritus: diagnosis and treatment of common symptoms in dialysis patients

JS Scherer, SA Combs, F Brennan - American Journal of Kidney Diseases, 2017 - Elsevier
Maintenance dialysis patients experience a high burden of physical and emotional
symptoms that directly affect their quality of life and health care utilization. In this review, we …

Multi-modal clique-graph matching for view-based 3D model retrieval

AA Liu, WZ Nie, Y Gao, YT Su - IEEE Transactions on Image …, 2016 - ieeexplore.ieee.org
Multi-view matching is an important but a challenging task in view-based 3D model retrieval.
To address this challenge, we propose an original multi-modal clique graph (MCG) …

Clinical presentation, management, and pathophysiology of neuropathic itch

M Steinhoff, M Schmelz, IL Szabó… - The Lancet …, 2018 - thelancet.com
Unlike conventional itch, neuropathic itch develops in normal skin from excess peripheral
firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom …

Dorsal horn gastrin-releasing peptide expressing neurons transmit spinal itch but not pain signals

GW Albisetti, M Pagani, E Platonova… - Journal of …, 2019 - Soc Neuroscience
Gastrin-releasing peptide (GRP) is a spinal itch transmitter expressed by a small population
of dorsal horn interneurons (GRP neurons). The contribution of these neurons to spinal itch …

Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

H Atilgan, M Doody, DK Oliver, TM McGrath… - Brain, 2022 - academic.oup.com
The claustrum is the most densely interconnected region in the human brain. Despite the
accumulating data from clinical and experimental studies, the functional role of the claustrum …