Two decades of Martini: Better beads, broader scope
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …
been around for nearly two decades. Originally developed for lipid‐based systems by the …
Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
[HTML][HTML] Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
[HTML][HTML] Interplay between lipid metabolism, lipid droplets, and DNA virus infections
MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …
[HTML][HTML] Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease
Oral administration facilitates the direct delivery of drugs to lesions within the small intestine
and colon, making it an ideal approach for treating patients with inflammatory bowel …
and colon, making it an ideal approach for treating patients with inflammatory bowel …
Tld1 is a regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation
NO Speer, RJ Braun, EG Reynolds, A Brudnicka… - Journal of Cell …, 2023 - rupress.org
Cells store lipids in the form of triglyceride (TG) and sterol ester (SE) in lipid droplets (LDs).
Distinct pools of LDs exist, but a pervasive question is how proteins localize to and convey …
Distinct pools of LDs exist, but a pervasive question is how proteins localize to and convey …
[HTML][HTML] Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease
X Li, J Ge, Y Li, Y Cai, Q Zheng, N Huang, Y Gu… - … Pharmaceutica Sinica B, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes of
chronic liver diseases and malignancies. However, few therapy has been approved. Radix …
chronic liver diseases and malignancies. However, few therapy has been approved. Radix …
Computational studies of lipid droplets
Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage.
Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure …
Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure …
LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy
M Omrane, KB M'Barek, A Santinho, N Nguyen… - Developmental Cell, 2023 - cell.com
Lipid droplets (LDs) store lipids that can be utilized during times of scarcity via autophagic
and lysosomal pathways, but how LDs and autophagosomes interact remained unclear …
and lysosomal pathways, but how LDs and autophagosomes interact remained unclear …