Levothyroxine, a largely prescribed drug with a narrow therapeutic index, is often a lifelong
treatment. The therapeutic efficacy of T4 may be marred by behavioral, pharmacologic, and …

Although levothyroxine is one of the most prescribed medications in the world, its
bioavailability has been reported to be impaired by many factors, including interfering drugs …

Background: A number of recent advances in our understanding of thyroid physiology may
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …

Purpose Levothyroxine (LT4) is a drug with a narrow therapeutic index, applied in small
amounts (micrograms), which makes interactions in the absorption phase clinically …

INTRODUCTION: Hypothyroidism has long been known for its effects on different organ
systems, leading to hypometabolism. However, subclinical hypothyroidism, its most …

Background: Levothyroxine (LT4) as a medication is used by up to 5.3% of the adult
population. For optimal efficacy, the traditional tablet formulation (LT4tab) requires that …

Levothyroxine is recognized as the treatment of choice for hypothyroidism. So far, the tablet
levothyroxine has been the formulation almost exclusively used, even though an optimal …

Most frequently, reasons for ineffectiveness are noncompliance, inappropriate
administration of levothyroxine, gastrointestinal disorders, and drug interactions. The …

Introdução: O hipotiroidismo é amplamente reconhecido por seus efeitos sobre os
diferentes sistemas orgânicos, levando ao hipometabolismo. No entanto, o hipotiroidismo …

Levothyroxine (L-T4) absorption can be impaired by various causes: a) L-T4 ingestion
during breakfast, or with food; b) conditions of reduced gastric acidity; c) intestinal …