From progenitors to progeny: shaping striatal circuit development and function

R Knowles, N Dehorter, T Ellender - Journal of Neuroscience, 2021 - Soc Neuroscience
Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …

Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

LP Fang, N Zhao, LC Caudal, HF Chang… - Nature …, 2022 - nature.com
Cortical neural circuits are complex but very precise networks of balanced excitation and
inhibition. Yet, the molecular and cellular mechanisms that form the balance are just …

CUT homeobox genes: transcriptional regulation of neuronal specification and beyond

E Leyva-Díaz - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
CUT homeobox genes represent a captivating gene class fulfilling critical functions in the
development and maintenance of multiple cell types across a wide range of organisms …

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

JJ Barron, NM Mroz, SE Taloma, MW Dahlgren… - Science, 2024 - science.org
The innate immune system shapes brain development and is implicated in
neurodevelopmental diseases. It is critical to define the relevant immune cells and signals …

Interneuron Diversity: How Form Becomes Function

NVDM García, G Fishell - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
A persistent question in neuroscience is how early neuronal subtype identity is established
during the development of neuronal circuits. Despite significant progress in the …

Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers

S Venkataramanappa, F Saaber, P Abe, D Schütz… - Cell Reports, 2022 - cell.com
The function of the cerebral cortex depends on various types of interneurons (cortical
interneurons [cINs]) and their appropriate allocation to the cortical layers. Caudal ganglionic …

Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity

N Döhne, A Falck, GMS Janach, E Byvaltcev… - Frontiers in cellular …, 2022 - frontiersin.org
Interferon-γ (IFN-γ), a cytokine with neuromodulatory properties, has been shown to
enhance inhibitory transmission. Because early inhibitory neurotransmission sculpts …

Developmental brain asymmetry. The good and the bad sides

ML Cara, I Streata, AM Buga, DG Iliescu - Symmetry, 2022 - mdpi.com
Brain asymmetry is a hallmark of the human brain. Recent studies report a certain degree of
abnormal asymmetry of brain lateralization between left and right brain hemispheres can be …

Neurophysiology of the developing cerebral cortex: What we have learned and what we need to know

HJ Luhmann - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
This review article aims to give a brief summary on the novel technologies, the challenges,
our current understanding, and the open questions in the field of the neurophysiology of the …

Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium

H Izumi, M Demura, A Imai, R Ogawa… - Frontiers in Molecular …, 2023 - frontiersin.org
Environmental and genetic factors influence synapse formation. Numerous animal
experiments have revealed that pesticides, including herbicides, can disturb normal …