Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly
due to a lack of genotype calling and quality-control procedures. Developing an at-scale …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Background While there is agreement that exercise is a powerful stimulus to increase both
mitochondrial function and content, we do not know the optimal training stimulus to …

Widespread aging at the population level is a recent phenomenon that emerged in affluent
societies. Inflammation is necessary to cope with damaging agents and is crucial for …

Publikace je určena kromě geriatrů zejména internistům a praktickým lékařům, užitečná je v
běžné praxi i v postgraduálním studiu. Kniha vymezuje geriatrického nemocného, popisuje …

Background: The aging phenotype in humans is very heterogeneous and can be described
as a complex mosaic resulting from the interaction of a variety of environmental, stochastic …

Aim: In the present study, we investigated whether global DNA methylation levels are
affected by mitochondrial DNA (mtDNA) variants, which are known to modulate …

Background Alzheimer's Disease (AD) is the most common neurodegenerative disease and
the leading cause of dementia among senile subjects. It has been proposed that AD can be …