Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …

GSK3 has been implicated for years in the regulation of inflammation and addressed in a
plethora of scientific reports using a variety of experimental (disease) models and …

Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of
rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …

The introduction of therapeutics targeting specific tumor-promoting oncogenic or non-
oncogenic signaling pathways has revolutionized cancer treatment. Mechanistic (previously …

Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and
cellular metabolism, are both coordinated by the primary cilium. Observations from cancer …

The epidermal growth factor receptor (EGFR) triggers the activation of many intracellular
signals that control cell proliferation, growth, survival, migration, and differentiation. Given its …

Malignant transformation and tumor progression are accompanied by significant
perturbations in metabolic programs. As such, cancer cells support high ATP turnover to …