Biological signaling pathways are underpinned by protein switches that sense and respond
to molecular inputs. Inspired by nature, engineered protein switches have been designed to …

Since the introduction of paper-based analytical devices as potential diagnostic platforms a
few decades ago, huge efforts have been made in this field to develop systems suitable for …

Heterogeneous immunoassays such as ELISA have become indispensable in modern
bioanalysis, yet translation into point-of-care assays is hindered by their dependence on …

Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase
inhibitors (CDKi's) as small molecule drugs and chemical probes of intracellular CDK …

Estrogen receptor alpha (ERα) is a ligand-dependent master transcriptional regulator and
key driver of breast cancer pathology. Small molecule hormones and competitive …

Compared to the traditional heterogeneous assays, a homogeneous immunoassay is a
preferred format for its simplicity. By cloning and isolating luminescent proteins from …

Homogeneous immunosensors integrate the advantages of both biosensors and
immunoassays; they include speed, high sensitivity, and accuracy. They have been …

C. difficile infection (CDI) is a leading healthcare-associated infection with a high morbidity
and mortality and is a financial burden. No current standalone point-of-care test (POCT) is …

The small engineered luciferase NanoLuc has rapidly become a powerful tool in the fields of
biochemistry, chemical biology, and cell biology due to its exceptional brightness and …

Cells use many post-translational modifications (PTMs) to tailor proteins and transduce
cellular signals. Recent years have witnessed the rapid growth of small molecule and …