Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

Oxidative stress has a significant impact on the development and progression of common
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …

The richened reactive oxygen species (ROS) and their derived excessive inflammation at
bone injured sites hinder osteogenesis of endosseous Ti‐based implants. Herein, anti …

Aminoacyl-tRNA synthetases (ARSs) are responsible for charging amino acids to cognate
tRNA molecules, which is the essential first step of protein translation. Interestingly …

The relative importance of regulation at the mRNA versus protein level is subject to ongoing
debate. To address this question in a dynamic system, we mapped proteomic and …

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that catalyze the first reaction
in protein biosynthesis, namely the charging of transfer RNAs (tRNAs) with their cognate …

Dominant mutations in tyrosyl-tRNA synthetase (YARS1) and six other tRNA ligases cause
Charcot-Marie-Tooth peripheral neuropathy (CMT). Loss of aminoacylation is not required …

Abstract tRNA fragmentation is an evolutionarily conserved molecular phenomenon. tRNA-
derived small RNAs (tsRNAs) have been associated with many cellular processes, including …

Artesunate, a semi-synthetic derivative of arteminisin originally developed for the treatment
of malaria, has recently been shown to possess antitumor properties. One of the cytotoxic …

Tyrosyl-tRNA synthetase (TyrRS) is well known for its essential aminoacylation function in
protein synthesis. Recently, TyrRS has been shown to translocate to the nucleus and protect …