Conformational changes underpin function and encode complex biomolecular mechanisms.
Gaining atomic-level detail of how such changes occur has the potential to reveal these …

Conformational changes (ie, dynamic transitions between pairs of conformational states)
play important roles in many chemical and biological processes. Constructing the Markov …

Self-assembly provides a powerful tool to fabricate advanced materials through the bottom-
up approach. Understanding the kinetics of self-assembly would thus greatly help achieve …

A yet unresolved challenge in structural biology is to quantify the conformational states of
proteins underpinning function. This challenge is particularly acute for membrane proteins …

Data produced by hydrogen-exchange monitoring experiments have been used in structural
studies of molecules for several decades. Despite uncertainties about the structural …

Protein conformational changes play crucial roles in their biological functions. In recent
years, the Markov State Model (MSM) constructed from extensive Molecular Dynamics (MD) …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) probes dynamic motions of
proteins by monitoring the kinetics of backbone amide deuteration. Dynamic regions exhibit …

Hydrogen-deuterium exchange combined with mass spectrometry (HDX-MS) is a widely
applied biophysical technique that probes the structure and dynamics of biomolecules …

Hydrogen-deuterium exchange (HDX) measured by nuclear magnetic resonance (NMR)
provides structural information for proteins relating to solvent accessibility and flexibility …

Previous reports present different models for the stabilization of the Fc—FcγRI immune
complex. Although accord exists on the importance of L235 in IgG1 and some hydrophobic …