The past decade has seen several critical advances in our understanding of hypothalamic–
pituitary–adrenal (HPA) axis regulation. Homeostatic physiological circuits need to integrate …

The hypothalamo-pituitary-adrenocortical (HPA axis) is required for stress adaptation.
Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ …

The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

The hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine network that controls
hormonal responses to internal and external challenges in an organism's environment …

Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum
drug that in recent years has drawn increasing interest as a treatment for a range of …

Glucocorticoid stress hormones are crucially involved in modulating mnemonic processing
of emotionally arousing experiences. They enhance the consolidation of new memories …

Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …

The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

Major depressive disorder is a common psychiatric disorder associated with marked
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …

Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented
phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different …