We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Background Homocysteine is a risk factor for Alzheimer's disease. In the first report on the
VITACOG trial, we showed that homocysteine‐lowering treatment with B vitamins slows the …

The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

Background Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12
intake in relation to cognitive function is limited, especially in midlife. Objective We …

Objective Moderately elevated levels of plasma total homocysteine are associated with an
increased risk of developing Alzheimer's disease. We have tested whether baseline …

There is strong evidence that homocysteine is a risk factor not only for cerebrovascular
diseases but also for degenerative dementias. A recent consensus statement renewed the …

Vitamin B-12 deficiency is often associated with cognitive deficits. Here we review evidence
that cognition in the elderly may also be adversely affected at concentrations of vitamin B-12 …

Obective: High homocysteine (Hct) has been causatively linked to Alzheimer disease (AD)
and vascular dementia (VaD) in old age, but research methodologies and outcome …