Common medical procedures to assess and treat patients can cause significant pain and
distress. Clinicians should have a basic approach for minimizing pain and distress in …

Objectives The objective of this study was to synthesize indication-based evidence for N2O
for distress and pain in children. Study design We included trials of N2O in participants 0–21 …

Background To evaluate the safety and effectiveness of different dosages of intranasal
Dexmedetomidine (DEX) in combination with oral midazolam for sedation of young children …

Vitamin B 12 deficiency is traditionally treated with intramuscular injections of cobalamin,
which are stressful events for children. In adults, studies have shown adequate absorption of …

Study objective To determine the optimal sedative dose of intranasal dexmedetomidine for
children undergoing laceration repair. Methods This dose-ranging study employing the …

Procedural sedation for diagnostic examination is a common practice in children. The study
aims to analyze the sedative effect and safety of intranasal dexmedetomidine combined with …

Objectives Intranasal dexmedetomidine is a potentially effective anxiolytic but its role in
pediatric laceration repair is only emerging. Future trials and clinical adoption of intranasal …

Background The exact median effective dose (ED50) of intranasal dexmedetomidine
combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination …

Background/Aims: Multi-arm, multi-stage trials frequently include a standard care to which all
interventions are compared. This may increase costs and hinders comparisons among the …

Objectives To systematically appraise the literature on the relative effectiveness of
pharmacologic procedural distress management agents for children undergoing laceration …