Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …

Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2)
protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …

Parkinson's disease is a debilitating, age-associated movement disorder. A central aspect of
the pathophysiology of Parkinson's disease is the progressive demise of midbrain dopamine …

Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …