Neutralizing antibodies (NAbs) can be both sufficient and necessary for protection against
viral infections, although they sometimes act in concert with cellular immunity. Successful …

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative
diseases. Tau can be targeted by using passively transferred antibodies (Abs), but the …

During pathogen infection, antibodies can be carried into the infected cell, where they are
detected by the ubiquitously expressed cytosolic antibody receptor TRIM21. Here we found …

Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor
that provides a last line of defense against invading viruses. It does so by acting as a sensor …

Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the
cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports …

Human innate immunity responds to viral infection by activating the production of interferons
(IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a …

Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the
RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion …

Adenovirus is a highly evolutionary successful pathogen, as it is widely prevalent across the
animal kingdom, infecting hosts ranging from lizards and frogs to dolphins, birds, and …

Nucleoprotein (N) is an immunodominant antigen in many enveloped virus infections. While
the diagnostic value of anti‐N antibodies is clear, their role in immunity is not. This is …