Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …

Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an
apparent involvement in biological processes ranging from mammary gland involution to …

Clusterin is a highly conserved protein which is expressed at increased levels by many cell
types in response to a broad variety of stress conditions. A genuine physiological function for …

Nuclear clusterin (nCLU) is an ionizing radiation (IR)-inducible protein that binds Ku70, and
triggers apoptosis when overexpressed in MCF-7 cells. We demonstrate that endogenous …

Clusterin/Apolipoprotein J (ApoJ) is a heterodimeric highly conserved secreted glycoprotein
being expressed in a wide variety of tissues and found in all human fluids. Despite being …

Figure 1 Predicted structure of clusterin. The cartoon shows mature human clusterin after
cleavage of its 22-mer signal peptide and internal cleavage at its Arg227–Ser228 bond …

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal
endothelial cells, thickening of Descement's membrane and deposition of extracellular …

We recently reported that the ubiquitous, secreted protein clusterin has chaperone activity in
vitro [Humphreys et al.(1999) J. Biol. Chem. 274, 6875− 6881]. In this study, we demonstrate …

There exists a family of currently untreatable, serious human diseases that arise from the
inappropriate misfolding and aggregation of extracellular proteins. At present our …