The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

P Nombela, B Miguel-López, S Blanco - Molecular cancer, 2021 - Springer
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer

H Huang, H Weng, J Chen - Cancer cell, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …

The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

The role of the pentose phosphate pathway in diabetes and cancer

T Ge, J Yang, S Zhou, Y Wang, Y Li… - Frontiers in …, 2020 - frontiersin.org
The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P),
produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic …

O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner

Y Yang, Y Yan, J Yin, N Tang, K Wang… - … and Targeted Therapy, 2023 - nature.com
Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC),
but its pathogenic mechanism remains to be explored. The RNA N6-methyladenosine (m6A) …

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP …

D Jin, J Guo, Y Wu, L Yang, X Wang, J Du, J Dai… - Molecular Cancer, 2020 - Springer
Background The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis,
decay, and translation control is an emerging research focus. Ectopically activated YAP is …

The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis

M Chen, CM Wong - Molecular cancer, 2020 - Springer
Liver cancer is a common cancer worldwide. Although the etiological factors of liver
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Y Xu, D Lv, C Yan, H Su, X Zhang, Y Shi, K Ying - Cancer cell international, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) has emerged as a significant regulator of
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …

m6A-binding proteins: the emerging crucial performers in epigenetics

Y Zhao, Y Shi, H Shen, W Xie - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is a well-known post-transcriptional modification that
is the most common type of methylation in eukaryotic mRNAs. The regulation of m 6 A is …

The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms

Q Huang, J Mo, Z Liao, X Chen, B Zhang - Cell Death & Disease, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …