Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation
ST Lubejko, G Livrizzi, SA Buczynski, J Patel… - Science …, 2024 - science.org
The supraspinal descending pain modulatory system (DPMS) shapes pain perception via
monoaminergic modulation of sensory information in the spinal cord. However, the role and …
monoaminergic modulation of sensory information in the spinal cord. However, the role and …
Opposing Effects on Descending Control of Nociception by µ and κ Opioid Receptors in the Anterior Cingulate Cortex
Background The efficiency of descending pain modulation, commonly assessed with the
conditioned pain modulation procedure, is diminished in patients with chronic pain. The …
conditioned pain modulation procedure, is diminished in patients with chronic pain. The …
The psychophysiology of music-based interventions and the experience of pain
CA Arnold, MK Bagg, AR Harvey - Frontiers in Psychology, 2024 - frontiersin.org
In modern times there is increasing acceptance that music-based interventions are useful
aids in the clinical treatment of a range of neurological and psychiatric conditions, including …
aids in the clinical treatment of a range of neurological and psychiatric conditions, including …
[HTML][HTML] The circuit basis for chronic pain and its comorbidities
R Patel - Current Opinion in Supportive and Palliative Care, 2023 - journals.lww.com
Comorbid pain and mood disorders can produce circuit-specific maladaptive plasticity;
however, several translational issues require addressing to maximise future therapeutic …
however, several translational issues require addressing to maximise future therapeutic …
Aged females unilaterally hypersensitize, lack descending inhibition, and overexpress alpha1D adrenergic receptors in a murine posttraumatic chronic pain model
SJ Hirsch, A Budig, S Husam, F Birklein - Pain, 2024 - journals.lww.com
Vulnerability to chronic pain is found to depend on age and sex. Most patients with chronic
pain are elderly women, especially with posttraumatic pain after bone fracture that prevails …
pain are elderly women, especially with posttraumatic pain after bone fracture that prevails …
[HTML][HTML] Multiple Posterior Insula Projections to the Brainstem Descending Pain Modulatory System
D Liang, C Labrakakis - International Journal of Molecular Sciences, 2024 - mdpi.com
The insular cortex is an important hub for sensory and emotional integration. It is one of the
areas consistently found activated during pain. While the insular's connections to the limbic …
areas consistently found activated during pain. While the insular's connections to the limbic …
Sex differences in descending control of nociception (DCN) responses after chronic orofacial pain induction in rats and the contribution of kappa opioid receptors
F Fiatcoski, CHA Jesus, J de Melo Turnes… - Behavioural Brain …, 2024 - Elsevier
Descending control of nociception (DCN), a measure of efficiency of descending pain
inhibition, can be assessed in animals by the combined application of test and conditioning …
inhibition, can be assessed in animals by the combined application of test and conditioning …
Mu opioid receptors gate the locus coeruleus pain generator
MR Norris, CC Kuo, SS Dunn, JR Kim, LJ Becker… - bioRxiv, 2023 - biorxiv.org
The locus coeruleus (LC) plays a paradoxical role in chronic pain. Although largely known
as a potent source of endogenous analgesia, increasing evidence suggests injury can …
as a potent source of endogenous analgesia, increasing evidence suggests injury can …
Conditioned pain modulation of pressure pain is associated with reduced activation in the parietal operculum and posterior insula
Conditioned pain modulation (CPM) is the phenomenon of pain inhibiting further pain. CPM
is impaired in patients suffering from various chronic pain conditions and may resemble a …
is impaired in patients suffering from various chronic pain conditions and may resemble a …
[PDF][PDF] Accepted Preproof
E Navratilova, C Qu, G Ji, V Neugebauer, M Guerrero… - 2023 - researchgate.net
Background: The efficiency of descending pain modulation, commonly assessed with the
conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain …
conditioned pain modulation (CPM) procedure, is diminished in patients with chronic pain …