Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon are frequently
prescribed oral anticoagulants to treat and prevent thromboembolism. Because there is a …

Concomitant administration of multiple drugs can lead to unanticipated drug interactions and
resultant adverse drug events with their associated costs. A more thorough understanding of …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

Stroke remains a leading cause of death worldwide and the first cause of disability in the
western world. Ischemic stroke (IS) accounts for almost 80% of the total cases of strokes and …

A new generation of technologies commonly named omics permits assessment of the
entirety of the components of biological systems and produces an explosion of data and a …

Since the introduction in the 1950s, warfarin has become the commonly used oral
anticoagulant for the prevention of thromboembolism in patients with deep vein thrombosis …

Objective: To systematically review evidence on genetic variants influencing outcomes
during warfarin therapy and provide practice recommendations addressing the key …

Prediction models are the key to individualized drug therapy. Warfarin is a typical example of
where pharmacogenetics could help the individual patient by modeling the dose, based on …

Variable warfarin response during treatment initiation poses a significant challenge to
providing optimal anticoagulation therapy. We investigated the determinants of initial …

Treatment response variability across patients is a common phenomenon in clinical practice.
For many drugs this inter-individual variability does not require much (if any) …