Metal and redox modulation of cysteine protein function
NM Giles, AB Watts, GI Giles, FH Fry, JA Littlechild… - Chemistry & biology, 2003 - cell.com
In biological systems, the amino acid cysteine combines catalytic activity with an extensive
redox chemistry and unique metal binding properties. The interdependency of these three …
redox chemistry and unique metal binding properties. The interdependency of these three …
E3 ubiquitin ligases as cancer targets and biomarkers
Y Sun - Neoplasia, 2006 - Elsevier
E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the
turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El …
turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El …
SCF E3 ubiquitin ligases as anticancer targets
L Jia, Y Sun - Current cancer drug targets, 2011 - ingentaconnect.com
The SCF (Skp1, Cullins, F-box proteins) multisubunit E3 ubiquitin ligase, also known as CRL
(Cullin-RING ubiquitin Ligase) is the largest E3 ubiquitin ligase family that promotes the …
(Cullin-RING ubiquitin Ligase) is the largest E3 ubiquitin ligase family that promotes the …
Targeting E3 ubiquitin ligases for cancer therapy
Y Sun - Cancer biology & therapy, 2003 - Taylor & Francis
E3 ubiquitin ligases are a large family of proteins that can be classified into three major
structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C …
structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C …
Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
JM Tokarew, DN El-Kodsi, NA Lengacher, TK Fehr… - Acta …, 2021 - Springer
The mechanisms by which parkin protects the adult human brain from Parkinson disease
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …
[HTML][HTML] Cullin-RING Ligase 5: Functional characterization and its role in human cancers
Abstract Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …
[HTML][HTML] Anticancer drug discovery by targeting cullin neddylation
Q Yu, Y Jiang, Y Sun - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Protein neddylation is a post-translational modification which transfers the ubiquitin-like
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …
Cardiovascular diseases and zinc
S Ozyildirim, SB Baltaci - Biological Trace Element Research, 2023 - Springer
Zinc is structurally and functionally essential for more than 300 enzymes and 2000
transcription factors in human body. Intracellular labile zinc is the metabolically effective zinc …
transcription factors in human body. Intracellular labile zinc is the metabolically effective zinc …
Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells
D Yang, L Li, H Liu, L Wu, Z Luo, H Li… - Cell Death & …, 2013 - nature.com
Abstract Regulator of Cullins-1 (ROC1) or RING box protein-1 (RBX1) is an essential RING
component of Cullin-RING ligase (CRL). Our previous studies showed that ROC1 is required …
component of Cullin-RING ligase (CRL). Our previous studies showed that ROC1 is required …
Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis
Hepatitis B virus (HBV) infection is a major public health problem. The high levels of HBV
DNA and HBsAg are positively associated with the development of secondary liver …
DNA and HBsAg are positively associated with the development of secondary liver …