The Aminoacyl-tRNA Synthetases (aaRSs) are an evolutionarily ancient family of enzymes
that catalyze the esterification reaction linking a transfer RNA (tRNA) with its cognate amino …

Ubiquitously expressed aminoacyl-tRNA synthetases play essential roles in decoding
genetic information required for protein synthesis in every living species. Growing evidence …

Aminoacyl-tRNA synthetases (ARSs) are highly conserved essential enzymes that charge
tRNA with cognate amino acids—the first step of protein synthesis. Of the 37 nuclear …

Fluctuations in the number of regulatory molecules and differences in timings of molecular
events can generate variation in gene expression among genetically identical cells in the …

Medulloblastoma (MB) is the most common malignant brain tumour in children. High-risk MB
patients harbouring MYC amplification or overexpression exhibit a very poor prognosis …

The AKT signaling pathway plays critical roles in the resolution of inflammation. However,
the underlying mechanisms of anti-inflammatory regulation and signal coordination remain …

Over the course of evolution, many proteins have undergone adaptive structural changes to
meet the increasing homeostatic regulatory demands of multicellularity. Aminoacyl tRNA …

Seryl-tRNA synthetases (SerRSs), members of the aminoacyl-tRNA synthetase family,
interact with diverse proteins, enabling SerRSs to enhance their role in the translation of the …

Hepatocellular carcinoma (HCC) is the second prominent cause of cancer-associated death
worldwide. Usually, HCC is diagnosed in advanced stages, wherein sorafenib, a multiple …

The identification of new cancer-associated genes/proteins, the characterization of their
expression variation, the interactomics-based assessment of differentially expressed …