The adaptation of adenoviruses as gene delivery tools has resulted in the development of
high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or “gutless” …

Oncolytic adenovirus therapy is believed to be a promising way to treat cancer patients. To
be able to target tumor cells with an oncolytic adenovirus, expression of the adenovirus …

Background: The Coxsackie-and Adenovirus Receptor (CAR) has been assigned two
crucial attributes in carcinomas:(a) involvement in the regulation of growth and …

Recombinant Adenoviral vectors represent one of the best gene transfer platforms due to
their ability to efficiently transduce a wide range of quiescent and proliferating cell types from …

The intestinal barrier plays a critical role in humans in the transport of nutrients and
macromolecules. At the same time, it has to provide an effective barrier to harmful …

Down syndrome (DS) is a developmental disorder whose mental impairment is due to
defective cortical development. Human neural progenitor cells (hNPCs) derived from fetal …

Background Viruses enter host cells through interactions of viral ligands with cellular
receptors. Viruses can also enter cells in a receptor-independent fashion. Mechanisms …

Oxidative stress has been implicated to play a role in a number of acute and chronic
diseases including acute injuries of the central nervous system, neurodegenerative and …

Sixteen years after Graham and coworkers described the most used system for generating
helper-dependent adenovirus (HDAd) vectors, production systems have evolved …

Leukocyte transmigration into the central nervous system promotes multiple sclerosis
pathogenesis, yet ambiguity remains regarding the mechanisms controlling the migration of …