Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Background Adolescent major depressive disorder (MDD) is a significant health problem,
associated with substantial morbidity, cost, and mortality. Depression is a significant risk …

Objective: Adolescent depression is prevalent and is associated with significant morbidity
and mortality. Although intravenous ketamine has shown efficacy in adult treatment-resistant …

Objective Suicide is a major cause of death in adolescents with limited treatment options.
Ketamine and its enantiomers have shown rapid anti-suicidal effects in adults with major …

Depression is more prevalent among adolescents than adults, but the underlying
mechanisms remain largely unknown. Using a subthreshold chronic stress model, here we …

Adolescence is a period of profound developmental changes, which run the gamut from
behavioral and neural to physiological and hormonal. It is also a time at which there is an …

Pediatric depression is a common psychiatric disorder that is associated with significant
morbidity and mortality. Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) …

The majority of antidepressant medication trials have focused on adult populations (ages 18–
65), with much less research in older and younger populations. Moreover, key differences in …

Suicide is the second leading cause of death in the United States among individuals aged
10–24, and severe youth depression is often refractory to the current standards of care …

Abstract Purpose of Review The following review will explore ketamine's antidepressant and
antisuicidal properties in adults, review of what is known about ketamine's safety in children …