Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors
M Ackermann, A Rafiei Hashtchin, F Manstein… - Nature protocols, 2022 - nature.com
Macrophages derived from human induced pluripotent stem cells (iPSCs) have the potential
to enable the development of cell-based therapies for numerous disease conditions. We …
to enable the development of cell-based therapies for numerous disease conditions. We …
Recent advances in plant nanoscience
Plants have complex internal signaling pathways to quickly adjust to environmental changes
and harvest energy from the environment. Facing the growing population, there is an urgent …
and harvest energy from the environment. Facing the growing population, there is an urgent …
A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response
Microglia are increasingly implicated in brain pathology, particularly neurodegenerative
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
[HTML][HTML] Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function
Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give
rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive …
rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive …
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss, with additional pathophysiological involvement of non …
progressive motor neuron loss, with additional pathophysiological involvement of non …
mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
F Ellett, L Pase, JW Hayman… - Blood, The Journal …, 2011 - ashpublications.org
Macrophages and neutrophils play important roles during the innate immune response,
phagocytosing invading microbes and delivering antimicrobial compounds to the site of …
phagocytosing invading microbes and delivering antimicrobial compounds to the site of …
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
To combat hostile viruses, bacteria and archaea have evolved a unique antiviral defense
system composed of clustered regularly interspaced short palindromic repeats (CRISPRs) …
system composed of clustered regularly interspaced short palindromic repeats (CRISPRs) …
Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo
Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …
Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions
B Wilgenburg, C Browne, J Vowles, SA Cowley - PloS one, 2013 - journals.plos.org
Human macrophages are specialised hosts for HIV-1, dengue virus, Leishmania and
Mycobacterium tuberculosis. Yet macrophage research is hampered by lack of appropriate …
Mycobacterium tuberculosis. Yet macrophage research is hampered by lack of appropriate …
[HTML][HTML] Human induced pluripotent stem cell-derived macrophages share ontogeny with MYB-independent tissue-resident macrophages
Tissue-resident macrophages, such as microglia, Kupffer cells, and Langerhans cells, derive
from Myb-independent yolk sac (YS) progenitors generated before the emergence of …
from Myb-independent yolk sac (YS) progenitors generated before the emergence of …