Pathophysiology of delayed cerebral ischemia after subarachnoid hemorrhage: a review
Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …
[HTML][HTML] Early brain injury after poor-grade subarachnoid hemorrhage
V Rass, R Helbok - Current neurology and neuroscience reports, 2019 - Springer
Abstract Purpose of Review Over the last years, the focus of clinical and animal research in
subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based …
subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based …
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study
JP Dreier, MKL Winkler, S Major, V Horst, S Lublinsky… - Brain, 2022 - academic.oup.com
Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results
from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The …
from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The …
[HTML][HTML] The critical role of spreading depolarizations in early brain injury: consensus and contention
Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …
[HTML][HTML] Central nervous system manifestations associated with COVID-19
Abstract Purpose of Review Coronavirus disease 2019 (COVID-19) has become a global
health crisis of our time. The disease arises from severe acute respiratory syndrome …
health crisis of our time. The disease arises from severe acute respiratory syndrome …
[HTML][HTML] Revisiting excitotoxicity in traumatic brain injury: from bench to bedside
D Baracaldo-Santamaría, DF Ariza-Salamanca… - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …
Consequences vary from mild cognitive impairment to death and, no matter the severity of …
Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury
MA MacLean, JH Muradov, R Greene… - Science …, 2023 - science.org
Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in
traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on …
traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on …
[HTML][HTML] Ketamine as an anesthetic for patients with acute brain injury: a systematic review
For years, the use of ketamine as an anesthetic to patients suffering from acute brain injury
has been debated because of its possible deleterious effects on the cerebral circulation and …
has been debated because of its possible deleterious effects on the cerebral circulation and …
[HTML][HTML] Noninvasive and reliable automated detection of spreading depolarization in severe traumatic brain injury using scalp EEG
Abstract Background Spreading depolarizations (SDs) are a biomarker and a potentially
treatable mechanism of worsening brain injury after traumatic brain injury (TBI). Noninvasive …
treatable mechanism of worsening brain injury after traumatic brain injury (TBI). Noninvasive …
[HTML][HTML] Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
Maintaining an adequate level of sedation and analgesia plays a key role in the
management of traumatic brain injury (TBI). To date, it is unclear which drug or combination …
management of traumatic brain injury (TBI). To date, it is unclear which drug or combination …