Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …

Fibrosis is the endpoint of pathological remodeling. This process contributes to the
pathogenesis of several chronic disorders and aging-associated organ damage. Different …

Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular …

Background IgG 4-related disease (IgG 4-RD) is a systemic condition of unknown cause
characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T …

Macrophages are found in close proximity with collagen-producing myofibroblasts and
indisputably play a key role in fibrosis. They produce profibrotic mediators that directly …

Myofibroblasts accumulate in the spaces between organ structures and produce
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …

Dysregulated wound healing leads to fibrosis, whereby fibroblasts synthesize excess
extracellular matrix and scarring impairs proper organ function. Although fibrotic diseases …

The pathogenesis of hepatic fibrosis involves significant deposition of fibrilar collagen and
other extracellular matrix proteins. It is a rather dynamic process of wound healing in …