Malaria is a threatening disease that has claimed many lives and has a high prevalence rate
annually. Through the past decade, there have been many studies to uncover effective …

Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …

Malaria remains a major public health problem. With the loss of antimalarials to resistance,
the malaria burden will likely continue for decades. New antimalarial scaffolds are crucial to …

Ethnopharmacological relevance Aloe marlothii A. Berger (Xanthorrhoeaceae) is
indigenous to southern African countries where its aqueous preparations are used in …

Background Emergence of cross-resistance to current anti-malarial drugs has led to an
urgent need for identification of potential compounds with novel modes of action and anti …

Background Herbal medicine has been a rich source of new drugs exemplified by quinine
and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') …

Background Male breast cancer (MBC) is usually diagnosed at late stages and therefore has
a worse prognosis than female breast cancer (FBC). MBC is also more likely to have lymph …

Two phenylpropanoid-conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin
(2), were isolated from the leaves of Morinda morindoides (Rubiaceae) by activity-guided …

Inhibition of cyclooxygenase-2 (COX-2) activity is an effective way for treatment of coronary
heart disease. And as an important source of COX-2 inhibitors, bioactive compounds of …

Background Natural products play a key role as potential sources of biologically active
substances for the discovery of new drugs. This study aimed to identify secondary …