BACKGROUND: N-acetylcysteine (NAC) has been in clinical practice for several decades. It
has been used as a mucolytic agent and for the treatment of numerous disorders including …

The model of cecal ligation and puncture (CLP) in rodents has been used extensively to
investigate the clinical settings of sepsis and septic shock. This model produces a …

Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality
mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing …

Regulated production of reactive oxygen species (ROS)/reactive nitrogen species (RNS)
adequately balanced by antioxidant systems is a prerequisite for the participation of these …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

SARS-CoV-2 has caused up to 127 million cases of COVID-19. Approximately 5% of COVID-
19 patients develop severe illness, and approximately 40% of those with severe illness …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Sepsis is the leading cause of death in medical intensive care units. In most fatal cases of
sepsis the patient experiences an insidious, progressive decline in vital organ function, ie …

We investigated a possible beneficial role for bilirubin, one of the products of heme
degradation by the cytoprotective enzyme heme oxygenase‐1 in counteracting Escherichia …

The generation of oxygen free radicals is known to be involved in the development of the
systemic inflammatory response syndrome. In addition to their actions as noxious mediators …