Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy
K Liu, X Zhang, L Xie, M Deng, H Chen, J Song… - Pharmacological …, 2021 - Elsevier
Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …
[HTML][HTML] EMT, CTCs and CSCs in tumor relapse and drug-resistance
Tumor relapse and metastasis are the primary causes of poor survival rates in patients with
advanced cancer despite successful resection or chemotherapeutic treatment. A primary …
advanced cancer despite successful resection or chemotherapeutic treatment. A primary …
[HTML][HTML] Cancer stem cells in the development of liver cancer
T Yamashita, XW Wang - The Journal of clinical …, 2013 - Am Soc Clin Investig
Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …
markers are useful for isolating a subset of liver cells with stem cell features, known as …
[HTML][HTML] The evolving concept of liver cancer stem cells
K Nio, T Yamashita, S Kaneko - Molecular cancer, 2017 - Springer
Liver cancer is an often fatal malignant tumor with a high recurrence rate and
chemoresistance. The major malignant phenotypes of cancer, including recurrence …
chemoresistance. The major malignant phenotypes of cancer, including recurrence …
[HTML][HTML] PTEN tumor-suppressor: the dam of stemness in cancer
F Luongo, F Colonna, F Calapà, S Vitale, ME Fiori… - Cancers, 2019 - mdpi.com
PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance
T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …
[HTML][HTML] Liver cancer stem cell markers: progression and therapeutic implications
Cancer stem cells (CSCs) are a small subpopulation in cancer, have been proposed to be
cancer-initiating cells, and have been shown to be responsible for chemotherapy resistance …
cancer-initiating cells, and have been shown to be responsible for chemotherapy resistance …
Multidrug efflux transporter ABCG2: expression and regulation
The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …
Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma
L Zheng, W Yang, F Wu, C Wang, L Yu, L Tang… - Clinical cancer …, 2013 - AACR
Purpose: The AMP-activated protein kinase (AMPK) serves as an energy sensor in
eukaryotic cells and occupies a central role in linking metabolism and cancer development …
eukaryotic cells and occupies a central role in linking metabolism and cancer development …