Machine learning for functional protein design
Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and
structure data have radically transformed computational protein design. New methods …
structure data have radically transformed computational protein design. New methods …
Customizing cellular signal processing by synthetic multi-level regulatory circuits
As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …
systems must be customized to meet practical demands. Towards this mission, novel …
The second decade of synthetic biology: 2010–2020
The second decade of synthetic biology: 2010–2020 | Nature Communications Skip to main
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content Thank you for visiting nature.com. You are using a browser version with limited support …
T cell circuits that sense antigen density with an ultrasensitive threshold
Overexpressed tumor-associated antigens [for example, epidermal growth factor receptor
(EGFR) and human epidermal growth factor receptor 2 (HER2)] are attractive targets for …
(EGFR) and human epidermal growth factor receptor 2 (HER2)] are attractive targets for …
De novo design of bioactive protein switches
Allosteric regulation of protein function is widespread in biology, but is challenging for de
novo protein design as it requires the explicit design of multiple states with comparable free …
novo protein design as it requires the explicit design of multiple states with comparable free …
De novo design of transmembrane β barrels
INTRODUCTION Despite their key biological roles, only a few proteins that fold into lipid
membranes have been designed de novo. A class of membrane proteins—transmembrane …
membranes have been designed de novo. A class of membrane proteins—transmembrane …
Genetic circuit design automation for yeast
Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …
Design automation software maps a desired circuit function to a DNA sequence, a process …
Engineering longevity—design of a synthetic gene oscillator to slow cellular aging
Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …
Programmable protein circuit design
Z Chen, MB Elowitz - Cell, 2021 - cell.com
A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …
[HTML][HTML] De novo protein design—From new structures to programmable functions
T Kortemme - Cell, 2024 - cell.com
Methods from artificial intelligence (AI) trained on large datasets of sequences and
structures can now" write" proteins with new shapes and molecular functions de novo …
structures can now" write" proteins with new shapes and molecular functions de novo …