Circadian rhythms and disorders of the timing of sleep

N Meyer, AG Harvey, SW Lockley, DJ Dijk - The Lancet, 2022 - thelancet.com
The daily alternation between sleep and wakefulness is one of the most dominant features
of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every …

Circadian rhythm as a therapeutic target

W Ruan, X Yuan, HK Eltzschig - Nature Reviews Drug Discovery, 2021 - nature.com
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

[HTML][HTML] Circadian rhythm disruption and mental health

WH Walker, JC Walton, AC DeVries… - Translational psychiatry, 2020 - nature.com
Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Circadian mechanisms in medicine

R Allada, J Bass - New England Journal of Medicine, 2021 - Mass Medical Soc
Circadian Mechanisms in Medicine Molecular insights into diurnal variations in human
physiology and behavior are extending our understanding of a wide range of disease …

Generation of circadian rhythms in the suprachiasmatic nucleus

MH Hastings, ES Maywood… - Nature Reviews …, 2018 - nature.com
The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …

[HTML][HTML] Rhythms of life: circadian disruption and brain disorders across the lifespan

RW Logan, CA McClung - Nature Reviews Neuroscience, 2019 - nature.com
Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Multifunctional fiber‐enabled intelligent health agents

M Chen, P Li, R Wang, Y Xiang, Z Huang… - Advanced …, 2022 - Wiley Online Library
The application of wearable devices is promoting the development toward digitization and
intelligence in the field of health. However, the current smart devices centered on human …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

[HTML][HTML] Genomics of circadian rhythms in health and disease

F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Circadian rhythm sleep–wake disturbances and depression in young people: implications for prevention and early intervention

JJ Crouse, JS Carpenter, YJC Song, SJ Hockey… - The Lancet …, 2021 - thelancet.com
A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …