Geroprotectors slow down aging and promote healthy longevity in model animals. Although
hundreds of compounds have been shown to extend the life of laboratory model organisms …

Breast cancer is the most common cancer and the most frequent cause of cancer death
among women worldwide. Breast cancer is a complex, heterogeneous disease classified …

Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

Background Resistance to endocrine therapy in breast cancer is associated with activation
of the mammalian target of rapamycin (mTOR) intracellular signaling pathway. In early …

Importance Estrogen receptor–positive (ER+) tumors of the breast are generally highly
responsive to endocrine treatment. Although endocrine therapy is the mainstay of adjuvant …

The phosphoinositide 3 kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin
(mTOR) pathway is a complicated intracellular pathway, which leads to cell growth and …

Gene expression profiling has reshaped our understanding of breast cancer by defining and
characterizing four main intrinsic molecular subtypes: human epidermal growth factor …

Abstract The phosphatidylinositol 3-kinase (PI3K) pathway has an important role in cell
metabolism, growth, migration, survival and angiogenesis. Drug development aimed at …

The advent of HER2-directed therapies has significantly improved the outlook for patients
with HER2-positive early stage breast cancer. However, a significant proportion of these …

The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …