Microbiota metabolites in health and disease

JL McCarville, GY Chen, VD Cuevas… - Annual review of …, 2020 - annualreviews.org
Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

Cancer related anemia: an integrated multitarget approach and lifestyle interventions

V Natalucci, E Virgili, F Calcagnoli, G Valli, D Agostini… - Nutrients, 2021 - mdpi.com
Cancer is often accompanied by worsening of the patient's iron profile, and the resulting
anemia could be a factor that negatively impacts antineoplastic treatment efficacy and …

A heritable iron memory enables decision-making in Escherichia coli

S Bhattacharyya, N Bhattarai… - Proceedings of the …, 2023 - National Acad Sciences
The importance of memory in bacterial decision-making is relatively unexplored. We show
here that a prior experience of swarming is remembered when Escherichia coli encounters a …

Antibiotic conjugates with an artificial MECAM-based siderophore are potent agents against Gram-positive and Gram-negative bacterial pathogens

L Pinkert, YH Lai, C Peukert, SK Hotop… - Journal of Medicinal …, 2021 - ACS Publications
The development of novel drugs against Gram-negative bacteria represents an urgent
medical need. To overcome their outer cell membrane, we synthesized conjugates of …

Deciphering links between bacterial interactions and spatial organization in multispecies biofilms

W Liu, S Jacquiod, A Brejnrod, J Russel… - The ISME …, 2019 - academic.oup.com
Environmental microbes frequently live in multispecies biofilms where mutualistic
relationships and co-evolution may occur, defining spatial organization for member species …

Antibacterial activity of SPIONs versus ferrous and ferric ions under aerobic and anaerobic conditions: a preliminary mechanism study

A Gholami, F Mohammadi, Y Ghasemi… - IET …, 2020 - Wiley Online Library
In modern medicine, major attention has been paid to superparamagnetic iron oxide
nanoparticles (SPIONs). Recent studies have shown the antibacterial properties of SPIONs …

[HTML][HTML] Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly

DJ Raines, JE Clarke, EV Blagova, EJ Dodson… - Nature Catalysis, 2018 - nature.com
Artificial metalloenzymes that contain protein-anchored synthetic catalysts are attracting
increasing interest. An exciting, but still unrealized advantage of non-covalent anchoring is …

Bacterial ABC transporters of iron containing compounds

P Delepelaire - Research in microbiology, 2019 - Elsevier
Iron acquisition is an essential aspect of cell physiology for most bacteria. Although much is
known about how bacteria initially recognize the various iron sources they can encounter …

Chemical and Biological Aspects of Nutritional Immunity—Perspectives for New Anti‐Infectives that Target Iron Uptake Systems

U Bilitewski, JAV Blodgett… - Angewandte Chemie …, 2017 - Wiley Online Library
Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of
essential metal ions, in particular iron, which leads to “nutritional immunity”. However …

Catch-and-Release: The Assembly, Immobilization, and Recycling of Redox-Reversible Artificial Metalloenzymes

AH Miller, EV Blagova, B Large, RL Booth… - ACS …, 2024 - ACS Publications
Technologies to improve the applicability of artificial metalloenzymes (ArMs) are gaining
considerable interest; one such approach is the immobilization of these biohybrid catalysts …