adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

Food is a potent natural reward and food intake is a complex process. Reward and
gratification associated with food consumption leads to dopamine (DA) production, which in …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …

Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

The neuronal circuitry underlying the complex relationship between stress, mood and food
intake are slowly being unravelled and several studies suggest a key role herein for the …

Ghrelin administration induces food intake and body weight gain. Based on these actions,
the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using …

Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite
and energy expenditure. Although some studies suggest that antagonizing ghrelin function …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is
characterized by the accumulation of intracellular α-synuclein aggregates and the …