Gene therapy holds great promise in the treatment of genetic diseases. It is now possible to
make DNA modifications using the CRISPR system. However, a major problem remains: the …

Gene therapy has shown great potential to treat various diseases by repairing the abnormal
gene function. However, a great challenge in bringing the nucleic acid formulations to the …

A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of
concern (VOCs) is a global health priority. Here, we develop lipid nanoparticles (LNPs) to …

Introduction Chimeric antigen receptor (CAR) cell therapy represents a hallmark in cancer
immunotherapy, with significant clinical results in the treatment of hematological tumors …

Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer,
and combating pandemics such as COVID-19 and its variants. Yet, the ability of LNPs to …

Cardiomyopathies are among the major triggers of heart failure, but their clinical and genetic
complexity have hampered our understanding of these disorders and delayed the …

mRNA-based gene editing platforms have tremendous promise in the treatment of genetic
diseases. However, for this potential to be realized in vivo, these nucleic acid cargos must …

Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …

Therapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer
therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver …

Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …