Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at
mitochondria during apoptosis to mediate mitochondrial permeabilization and …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

BAK and BAX are essential mediators of apoptosis that oligomerize in response to death
cues, thereby causing permeabilization of the mitochondrial outer membrane. Their …

Bilayered membranes separate cells from their surroundings and form boundaries between
intracellular organelles and the cytosol. Gated transport of solutes across membranes …

Despite the fact that copper (Cu) is a vital micronutrient to maintain body function, high
doses of Cu through environmental exposure damage various organs, especially the liver …

Apoptosis is a common cell death program that is important in human health and disease.
Signaling in apoptosis is largely driven through protein–protein interactions. The BCL-2 …

Doxorubicin (DOX), a chemotherapy drug widely recognized for its efficacy in cancer
treatment, unfortunately, has significant nephrotoxic effects leading to kidney damage. This …