This review adds the bilin-binding phytochromes to the Chemical Reviews thematic issue
“Optogenetics and Photopharmacology”. The work is structured into two parts. We first …

Genetically encoded tools for the regulation of endogenous molecules (RNA, DNA elements
and protein) are needed to study and control biological processes with minimal interference …

In mammalian cells, signalling pathways orchestrate cellular growth, differentiation and
survival, as well as many other processes that are essential for the proper functioning of …

We present a prototype and verification of a multichannel laser system applicable to
optogenetic research. In vivo photostimulation of neural cells expressing photoconvertible …

Biological signals are sensed by their respective receptors and are transduced and
processed by a sophisticated intracellular signaling network leading to a signal-specific …

Regulation of receptor tyrosine kinase (RTK) activity is necessary for studying cell signaling
pathways in health and disease. We developed a generalized approach for engineering …

Dynamic protein-protein interactions are essential for proper cell functioning. Homo-
interaction events—physical interactions between the same type of proteins—represent a …

A large percentage of proteins form higher-order structures in order to fulfill their function.
These structures are crucial for the precise spatial and temporal regulation of the cellular …

Optogenetic activation of intracellular signaling based on light-inducible protein-protein
homo-interactions Page 1 NEURAL REGENERATION RESEARCH|Vol 17|No. 1|January …

Optogenetic research has opened up the possibility to control neurons that will help detect
and treat neurological diseases in the early stage. Treatment of dysfunctions requires …