Solid-state NMR spectroscopy
Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to
determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This …
determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This …
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins
A polymer chain of N atoms enjoys 3N-6 internal degrees of freedom, which gives rise to
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …
Raman spectroscopic characterization of secondary structure in natively unfolded proteins: α-synuclein
NC Maiti, MM Apetri, MG Zagorski… - Journal of the …, 2004 - ACS Publications
The application of Raman spectroscopy to characterize natively unfolded proteins has been
underdeveloped, even though it has significant technical advantages. We propose that a …
underdeveloped, even though it has significant technical advantages. We propose that a …
Structure determination of membrane proteins by NMR spectroscopy
SJ Opella, FM Marassi - Chemical reviews, 2004 - ACS Publications
Much of postgenomic biochemistry and all of structural biology are based on the premise
that the starting point for both understanding specific biochemical processes, such as affinity …
that the starting point for both understanding specific biochemical processes, such as affinity …
Coarse-grained molecular dynamics simulations of membrane proteins and peptides
Molecular dynamics (MD) simulations provide a valuable approach to the dynamics,
structure, and stability of membrane–protein systems. Coarse-grained (CG) models, in which …
structure, and stability of membrane–protein systems. Coarse-grained (CG) models, in which …
Myelin basic protein—diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis
G Harauz, N Ishiyama, CMD Hill, IR Bates, DS Libich… - Micron, 2004 - Elsevier
The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin
sheath in the central nervous system of higher vertebrates, and a member of a larger family …
sheath in the central nervous system of higher vertebrates, and a member of a larger family …
Chemical shift tensor–The heart of NMR: Insights into biological aspects of proteins
H Saitô, I Ando, A Ramamoorthy - Progress in nuclear magnetic resonance …, 2010 - Elsevier
The chemical shift of a nucleus, i, in a molecule arises from the nuclear shielding effect of an
applied magnetic field, caused by an induced magnetic field resulting from circulation of …
applied magnetic field, caused by an induced magnetic field resulting from circulation of …
Toward high-resolution prediction and design of transmembrane helical protein structures
The prediction and design at the atomic level of membrane protein structures and
interactions is a critical but unsolved challenge. To address this problem, we have …
interactions is a critical but unsolved challenge. To address this problem, we have …
Three-dimensional structure of the channel-forming trans-membrane domain of virus protein “u”(Vpu) from HIV-1
SH Park, AA Mrse, AA Nevzorov, MF Mesleh… - Journal of molecular …, 2003 - Elsevier
The three-dimensional structure of the channel-forming trans-membrane domain of virus
protein “u”(Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer …
protein “u”(Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer …
Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method
Phospholamban (PLN) is a type II membrane protein that inhibits the sarcoplasmic reticulum
Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In …
Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In …