Chemo-and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review
Covering: up to 2014 In silico approaches have been widely recognised to be useful for drug
discovery. Here, we consider the significance of available databases of medicinal plants and …
discovery. Here, we consider the significance of available databases of medicinal plants and …
Medicinal plants used in the treatment of Malaria: A key emphasis to Artemisia, Cinchona, Cryptolepis, and Tabebuia genera
Malaria is one of the life‐threatening parasitic diseases that is endemic in tropical areas. The
increased prevalence of malaria due to drug resistance leads to a high incidence of …
increased prevalence of malaria due to drug resistance leads to a high incidence of …
Artificial intelligence and big data facilitated targeted drug discovery
B Liu, H He, H Luo, T Zhang, J Jiang - Stroke and vascular neurology, 2019 - svn.bmj.com
Different kinds of biological databases publicly available nowadays provide us a goldmine
of multidiscipline big data. The Cancer Genome Atlas is a cancer database including …
of multidiscipline big data. The Cancer Genome Atlas is a cancer database including …
QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα
Due to the high mortality rate in India, the identification of novel molecules is important in the
development of novel and potent anticancer drugs. Xanthones are natural constituents of …
development of novel and potent anticancer drugs. Xanthones are natural constituents of …
Drug target identification in protozoan parasites
J Müller, A Hemphill - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: Despite the fact that diseases caused by protozoan parasites represent serious
challenges for public health, animal production and welfare, only a limited panel of drugs …
challenges for public health, animal production and welfare, only a limited panel of drugs …
In Silico and In Vivo Anti-Malarial Studies of 18β Glycyrrhetinic Acid from Glycyrrhiza glabra
Malaria is one of the most prevailing fatal diseases causing between 1.2 and 2.7 million
deaths all over the world each year. Further, development of resistance against the frontline …
deaths all over the world each year. Further, development of resistance against the frontline …
QSAR modeling, docking and ADMET studies for exploration of potential anti-malarial compounds against Plasmodium falciparum
T Qidwai - In Silico Pharmacology, 2017 - Springer
Abstract Development of resistance in the Plasmodium falciparum to Artemisinin, the most
effective anti-malarial compound, threatens malaria elimination tactics. To gain more …
effective anti-malarial compound, threatens malaria elimination tactics. To gain more …
New approaches for the identification of drug targets in protozoan parasites
J Müller, A Hemphill - International review of cell and molecular biology, 2013 - Elsevier
Antiparasitic chemotherapy is an important issue for drug development. Traditionally, novel
compounds with antiprotozoan activities have been identified by screening of compound …
compounds with antiprotozoan activities have been identified by screening of compound …
QSAR and docking based semi-synthesis and in vivo evaluation of artemisinin derivatives for antimalarial activity
D Kumar Yadav, S Dhawan, A Chauhan… - Current drug …, 2014 - ingentaconnect.com
To screen the active antimalarial novel artemisinin derivatives, a QSAR modeling approach
was used. QSAR model showed high correlation (r2= 0.83 and rCV2= 0.81) and indicated …
was used. QSAR model showed high correlation (r2= 0.83 and rCV2= 0.81) and indicated …
Hepatotoxicity and lipid metabolism disorders of 8: 2 polyfluoroalkyl phosphate diester in zebrafish: In vivo and in silico evidence
P Chen, N Zhao, R Wang, G Chen, Y Hu, Z Dou… - Journal of Hazardous …, 2024 - Elsevier
2 polyfluoroalkyl phosphate diester (8: 2 diPAP) has been shown to accumulate in the liver,
but whether it induces hepatotoxicity and lipid metabolism disorders remains largely …
but whether it induces hepatotoxicity and lipid metabolism disorders remains largely …