Imprinted genes are a subset of mammalian genes that are subject to germline parent-
specific epigenetic modifications leading monoallelic expression. Imprinted gene expression …

DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane
protein Delta-like homologue 1 (DLK1), a non-canonical NOTCH ligand with well-described …

Mammalian parental imprinting represents an exquisite form of epigenetic control regulating
the parent-specific monoallelic expression of genes in clusters. While imprinting …

Background The exact mechanisms of type 2 diabetes mellitus (T2DM) remain largely
unknown. We intended to authenticate critical genes linked to T2DM progression by tandem …

How neuronal signaling affects brain myelination remains poorly understood. We show
dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination. Neuronal …

Adult neurogenesis is supported by multipotent neural stem cells (NSCs) with unique
properties and growth requirements. Adult NSCs constitute a reversibly quiescent cell …

Genomic imprinting is an epigenetic process through which genes are expressed in a parent-
of-origin specific manner resulting in mono-allelic or strongly biased expression of one …

Neural stem cells (NSCs) exhibit self-renewing and multipotential properties. Adult NSCs
are located in two neurogenic regions of adult brain: the ventricular-subventricular zone (V …

The ability of neural stem/progenitor cells (NSPCs) to proliferate and differentiate is required
through different stages of neurogenesis. Disturbance in the regulation of neurogenesis …

Progressive neuronal dysfunction and death are key features of neurodegenerative
diseases; therefore, promoting neurogenesis in neurodegenerative diseases is crucial. With …