Mitophagy in human diseases

L Doblado, C Lueck, C Rey, AK Samhan-Arias… - International journal of …, 2021 - mdpi.com
Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors

M Farshbafnadi, SK Zonouzi, M Sabahi… - Experimental …, 2021 - Elsevier
Abstract The emergence of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-
2) in late 2019 has been associated with a high rate of mortality and morbidity. It has been …

The multifaceted regulation of mitophagy by endogenous metabolites

T Zhang, Q Liu, W Gao, SA Sehgal, H Wu - Autophagy, 2022 - Taylor & Francis
Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …

Defective autophagy and mitophagy in aging and Alzheimer's disease

M Tran, PH Reddy - Frontiers in neuroscience, 2021 - frontiersin.org
Aging is the time-dependent process that all living organisms go through characterized by
declining physiological function due to alterations in metabolic and molecular pathways …

Antiaging agents: Safe interventions to slow aging and healthy life span extension

JK Liu - Natural Products and Bioprospecting, 2022 - Springer
Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

Nutrition strategies promoting healthy aging: From improvement of cardiovascular and brain health to prevention of age-associated diseases

M Fekete, Z Szarvas, V Fazekas-Pongor, A Feher… - Nutrients, 2022 - mdpi.com
Background: An increasing number of studies suggest that diet plays an important role in
regulating aging processes and modulates the development of the most important age …

Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease

S Kshirsagar, N Sawant, H Morton… - Human molecular …, 2022 - academic.oup.com
The purpose of our study is to determine the protective effects of mitophagy enhancers
against mutant APP and amyloid beta (Aβ)-induced mitochondrial and synaptic toxicities in …

Mitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases

E Mishra, MK Thakur - British Journal of Pharmacology, 2023 - Wiley Online Library
Mitochondria and mitochondria‐mediated signalling pathways are known to control synaptic
signalling, as well as long‐lasting changes in neuronal structure and function. Mitochondrial …

Mitochondria transfer in brain injury and disease

LH Fairley, A Grimm, A Eckert - Cells, 2022 - mdpi.com
Intercellular mitochondria transfer is a novel form of cell signalling in which whole
mitochondria are transferred between cells in order to enhance cellular functions or aid in …

Impact of polyphenolic-food on longevity: An elixir of life. An overview

R Meccariello, S D'Angelo - Antioxidants, 2021 - mdpi.com
Aging and, particularly, the onset of age-related diseases are associated with tissue
dysfunction and macromolecular damage, some of which can be attributed to accumulation …