[HTML][HTML] Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
[HTML][HTML] Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy
X Chang, X Feng, M Du, S Li, J Wang… - Frontiers in …, 2023 - frontiersin.org
Cancer represents one of the leading causes of mortality worldwide. Conventional clinical
treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy …
treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy …
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer
Introduction The resistance to chemotherapy is a significant hurdle in breast cancer
treatment, prompting the exploration of innovative strategies. This review discusses the …
treatment, prompting the exploration of innovative strategies. This review discusses the …
PEGylated nanoassemblies composed of edelfosine and fulvestrant drugs: In vitro antiproliferative effect against breast cancer cells
Abstract Edelfosine (EDL) and Fulvestrant (FUL), proven anticancer agents, suffer significant
limitations for low water solubility and poor bioavailability. FUL is an effective breast cancer …
limitations for low water solubility and poor bioavailability. FUL is an effective breast cancer …
Anticancer potential of Diospyrin and its analogues: An updated review
Cancer, characterized as one of the leading causes of death owing to its heterogeneity and
complexity, hence poses a significant challenge to health care system across the globe …
complexity, hence poses a significant challenge to health care system across the globe …
In-silico investigation of RPS6KB1 associated cancer inhibitor: a drug repurposing study
S Rajendrasozhan, I Ahmad… - Journal of …, 2024 - Taylor & Francis
The ribosomal protein S6 kinase beta-1 (RPS6KB1), also known as p70S6 kinase, plays a
crucial role in various disease-related conditions such as diabetes, obesity, and cancer. Its …
crucial role in various disease-related conditions such as diabetes, obesity, and cancer. Its …
Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
R Chowdhury, MS Bhuia, MS Al Hasan… - Food Science & …, 2024 - Wiley Online Library
Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can
infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well …
infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well …
In vivo evaluation of mebendazole and Ran GTPase inhibition in breast cancer model system
B Abu-Hdaib, H Nsairat, M El-Tanani, I Al-Deeb… - …, 2024 - Taylor & Francis
Aim: To investigate the therapeutic potential of mebendazole (MBZ)-loaded nanostructured
lipid carriers (NLCs). Methodology: NLC-MBZ was prepared and characterized to evaluate …
lipid carriers (NLCs). Methodology: NLC-MBZ was prepared and characterized to evaluate …
The potential role of circular RNAs-regulated PI3K signaling in non-small cell lung cancer: Molecular insights and clinical perspective
S Kahkesh, SM Khoshnazar, Y Gholinezhad… - … -Research and Practice, 2024 - Elsevier
Non-small cell lung cancer (NSCLC), accounting for more than 80% of all cases, is the
predominant form of lung cancer and the leading cause of cancer-related deaths worldwide …
predominant form of lung cancer and the leading cause of cancer-related deaths worldwide …
Hypoxia-associated autophagy flux dysregulation in human cancers
J Fu, J Lin, Z Dai, B Lin, J Zhang - Cancer Letters, 2024 - Elsevier
A general feature of cancer is hypoxia, determined as low oxygen levels. Low oxygen levels
may cause cells to alter in ways that contribute to tumor growth and resistance to treatment …
may cause cells to alter in ways that contribute to tumor growth and resistance to treatment …