The ROSMAP project: aging and neurodegenerative diseases through omic sciences
AP Pérez-González, AL García-Kroepfly… - Frontiers in …, 2024 - frontiersin.org
The Religious Order Study and Memory and Aging Project (ROSMAP) is an initiative that
integrates two longitudinal cohort studies, which have been collecting clinicopathological …
integrates two longitudinal cohort studies, which have been collecting clinicopathological …
A bibliometric and visual analysis of epigenetic research publications for Alzheimer's disease (2013–2023)
YP Zhao, WJ Ai, JF Zheng, XL Hu… - Frontiers in Aging …, 2024 - frontiersin.org
Background Currently, the prevalence of Alzheimer's disease (AD) is progressively rising,
particularly in developed nations. There is an escalating focus on the onset and progression …
particularly in developed nations. There is an escalating focus on the onset and progression …
Multi-omic atlas of the parahippocampal gyrus in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia worldwide, with a projection
of 151 million cases by 2050. Previous genetic studies have identified three main genes …
of 151 million cases by 2050. Previous genetic studies have identified three main genes …
Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's disease
INTRODUCTION DNA microarray‐based studies report differentially methylated positions
(DMPs) in blood between late‐onset dementia due to Alzheimer's disease (AD) and …
(DMPs) in blood between late‐onset dementia due to Alzheimer's disease (AD) and …
Quantitative relationships of FAM50B and PTCHD3 methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from …
C Wan, H Ma, J Liu, F Liu, J Liu, G Dong, X Zeng… - Science of The Total …, 2024 - Elsevier
At present, the application of DNA methylation (DNAm) biomarkers in environmental health
risk assessment (EHRA) is more challenging due to the unclearly quantitative relationship …
risk assessment (EHRA) is more challenging due to the unclearly quantitative relationship …
DNA methylation of imprint control regions associated with Alzheimer's disease in non-Hispanic Blacks and non-Hispanic Whites
Alzheimer's disease (AD) prevalence is twice as high in non-Hispanic Blacks (NHBs) as in
non-Hispanic Whites (NHWs). The objective of this study was to determine whether aberrant …
non-Hispanic Whites (NHWs). The objective of this study was to determine whether aberrant …
The broken Alzheimer's disease genome
The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant
challenges to therapeutic and preventative interventions. Despite these difficulties …
challenges to therapeutic and preventative interventions. Despite these difficulties …
Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease
DUSP4 is a member of the DUSP (dual-specificity phosphatase) subfamily that is selective
to the mitogen-activated protein kinases (MAPK) and has been implicated in a range of …
to the mitogen-activated protein kinases (MAPK) and has been implicated in a range of …
Sarcopenia as a Risk Factor for Alzheimer's Disease: Genetic and Epigenetic Perspectives
SM Raleigh, KJA Orchard - Genes, 2024 - mdpi.com
Sarcopenia, defined as the age-associated loss of muscle mass and increased fragility with
age, is increasing worldwide. The condition often precedes the development of Alzheimer's …
age, is increasing worldwide. The condition often precedes the development of Alzheimer's …
METTL Family in Health and Disease
J He, F Hao, S Song, J Zhang, H Zhou, J Zhang… - Molecular Biomedicine, 2024 - Springer
Transcription, RNA splicing, RNA translation, and post-translational protein modification are
fundamental processes of gene expression. Epigenetic modifications, such as DNA …
fundamental processes of gene expression. Epigenetic modifications, such as DNA …