Endogenous cardiotonic steroids (CTS), also called digitalis-like factors, have been
postulated to play important roles in health and disease for nearly half a century. Recent …

This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

Recent studies have ascribed many non-pumping functions to the Na/K-ATPase. Here, we
present experimental evidence demonstrating that over half of the plasma membrane Na/K …

Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-
dependent mechanism. Background We have demonstrated that ouabain causes dose-and …

A major difference between the Na, K-ATPase ion pump and other P-type ATPases is its
ability to bind cardiotonic steroids such as ouabain. Na, K-ATPase also interacts with many …

We have observed recently that experimental renal failure in the rat is accompanied by
increases in circulating concentrations of the cardiotonic steroid, marinobufagenin (MBG) …

It now generally is agreed that Na, K-ATPase, in addition to its role in the maintenance of
Na+ and K+ gradients across the cell membrane, plays a role in communicating information …

Cardiotonic steroids (such as ouabain) signaling through Na/K-ATPase regulate sodium
reabsorption in the renal proximal tubule. We report here that reactive oxygen species are …

Endogenous digitalis-like factors, also called cardiotonic steroids, have been thought for
nearly half a century to have important roles in health and disease. The endogenous …

The Na/K-ATPase was discovered as an energy transducing ion pump. A major difference
between the Na/K-ATPase and other P-type ATPases is its ability to bind a group of …