Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

Background Accurate prediction of treatment response to neoadjuvant chemotherapy
(NACT) in individual patients with locally advanced gastric cancer (LAGC) is essential for …

In the era of immunotherapy, identifying biomarkers of immune system activation has
become a high-priority challenge. The blood neutrophil-to-lymphocyte ratio (NLR) has been …

The tumor immune microenvironment (TIME) is associated with tumor prognosis and
immunotherapy response. Here we develop and validate a CT-based radiomics score (RS) …

Background Peroxisome proliferator-activated receptor delta (PPARδ) promotes
inflammation and carcinogenesis in many organs, but the underlying mechanisms remains …

Prospective evidence regarding the combination of programmed cell death (PD)− 1 and
angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this …

Objective To evaluate the prognostic significance of peripheral lymphocyte count and its
derived inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), in a cohort of …

Background: Recently, many studies have explored the relationship between the expression
of programmed death ligand 1 (PD-L1) and prognosis in gastric cancer, but there is still …

Introduction Cachexia is associated with poor survival of patients with bile duct cancer. The
cachexia index (CXI), which comprises skeletal muscle, inflammation, and nutritional status …

Background Limited benefit population of immunotherapy makes it urgent to select effective
biomarkers for screening appropriate treatment population. Herein, we have investigated the …