• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …

Health professionals are encouraged to take the Guidelines fully into account when
exercising their clinical judgment, as well as in the determination and the implementation of …

Background Peptic ulcer disease (PUD) is a common digestive disorder, of which the
prevalence decreased in the past few decades. However, the decreasing tendency has …

Background Diabetes mellitus is associated with an increased risk of cardiovascular events.
Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; …

Abstract The Japanese Society of Gastroenterology (JSGE) revised the third edition of
evidence-based clinical practice guidelines for peptic ulcer disease in 2020 and created an …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, widely used analgesics. For
the past 2 decades, considerable attention has been focused on their cardiovascular safety …

This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

Peptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that
may reach the muscle layer. Their etiology is multifactorial and occurs when the balance …

Objective To estimate all cause mortality and cause specific mortality among patients taking
proton pump inhibitors (PPIs). Design Longitudinal observational cohort study. Setting US …