The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Care of burn-injured patients requires knowledge of the pathophysiologic changes affecting
virtually all organs from the onset of injury until wounds are healed. Massive airway and/or …

Opioid Tolerance in Critical Illness | NEJM Skip to main content NEJM Group Follow Us
Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build your …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

O uso do canabidiol em algumas condições neurológicas foi liberado pelo Conselho
Regional de Medicina de São Paulo e pela Agência Nacional de Vigilância Sanitária …

Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of
anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH …

Background Modulation of the endocannabinoid system has been shown to alleviate
neuropathic pain. The aim of this study was to evaluate if treatment with paclitaxel, a …

There is considerable evidence to support the role of anandamide (AEA), an endogenous
ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects …

Effective treatments for pain management remain elusive due to the dangerous side-effects
of current gold-standard opioid analgesics, including the respiratory depression that has led …

Cannabinoid-based therapies have long been used to treat pain, but there remain questions
about their actual mechanisms and efficacy. From an evolutionary perspective, the …