Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in
response to disruptions to cellular homeostasis. The process of exerciseinduced adaptation …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological
and metabolic parameters. It is this diversity that enables different muscle groups to provide …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Schoenfeld, BJ. Does exercise-induced muscle damage play a role in skeletal muscle
hypertrophy? J Strength Cond Res 26 (5): 1441–1453, 2012—Exercise-induced muscle …

Mammalian skeletal muscles are composed of a variety of highly specialized fibers whose
selective recruitment allows muscles to fulfill their diverse functional tasks. In addition …