Curcumin is a polyphenol natural product isolated from turmeric, interacting with different
cellular and molecular targets and, consequently, showing a wide range of pharmacological …

Abstract Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit
proinflammatory responses of both innate and adaptive immune cells. An association …

Phloretin, extracted from the pericarp and velamen of apples or pears, is a dihydrochalcone
flavonoid with anti-bacterial and anti-inflammatory activities. It has been reported that …

Oral immunotherapy has had limited success in establishing tolerance in food allergy,
reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease …

CD4+ CD25+ Foxp3+ regulatory T (Treg) cells are essential to the balance between pro-and
anti-inflammatory responses. There are two major subsets of Treg cells,“natural” Treg …

Regulatory T cells (Treg cells) deficient in the transcription factor Foxp3 lack suppressor
function and manifest an effector T (Teff) cell–like phenotype. We demonstrate that Foxp3 …

Regulatory T (Treg) cells are potent suppressors that maintain immune homeostasis.
Accumulation of Treg can inhibit effective immune responses in cancer patients, leading to …

The mucosal immune system mediates contact between the host and the trillions of
microbes that symbiotically colonize the gastrointestinal tract. Failure to tolerate the antigens …

Commensal microbiota promote mucosal tolerance in part by engaging regulatory T (Treg)
cells via Toll-like receptors (TLRs). We report that Treg-cell-specific deletion of the TLR …

Receptors of the Notch family direct the differentiation of helper T cell subsets, but their
influence on regulatory T cell (T reg cell) responses is obscure. We found here that lineage …