Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

Highlights•Neurexins are central synaptic organizers implicated in neuropsychiatric
diseases.•Together with their partners, neurexins form transsynaptic bridges that span the …

Neurexins are presynaptic transmembrane proteins crucial for synapse development and
organization. Deletion and missense mutations in all three Neurexin genes have been …

A single-molecule three-dimensional (3D) structure is essential for understanding the
thermal vibrations and dynamics as well as the conformational changes during the chemical …

Background Rare genetic variants contribute to the etiology of both autism spectrum
disorder (ASD) and schizophrenia (SCZ). Most genetic studies limit their focus to likely gene …

The potent neurotoxic venom of the black widow spider contains a cocktail of seven phylum-
specific latrotoxins (LTXs), but only one, α-LTX, targets vertebrates. This 130 kDa toxin binds …

Simple Summary Bladder cancer is one of the most common malignant tumors of the urinary
system, and its treatment is mainly surgical resection, supplemented by chemotherapy after …

α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that
are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their …

Hevin is secreted by astrocytes and its synaptogenic effects are antagonized by the related
protein, SPARC. Hevin stabilizes neurexin-neuroligin transsynaptic bridges in vivo. A third …

Aim: This study examined the roles of the laminin and proteoglycan receptor dystroglycan
(DG) in extracellular matrix stabilization and cellular mechanosensory processes conveyed …